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NPs-induced downregulation of endothelial nitric oxide synthase (eNOS) expression, causing impaired endothelium-dependent vasorelaxation and promoting reactive oxygen species creation in endothelial cells, which was associated with high NADPH oxidase expression, with subsequent downregulation of Sirt1 expression [76]
however, the markers upregulated from T-cell exhaustion may remain up to 1 year in PASC patients 213,214
GLP-1 exerts its anorectic effect in part by acting on the hunger-satiety centre located in the arcuate nucleus of the hypothalamus, and in part by delaying gastric emptying
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