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DOI:10.1096/fasebj.2019.33.1\_supplement.822.4

Genetic variations (polymorphism) in P-450 metabolism should be considered when patients exhibit unusual sensitivity or resistance to drug effects at normal doses

IB- phosphorylation is an early-stage event in NF-B activation and plays a central role in the determination of the subsequent steps involved in the nuclear translocation of p65/p50