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For women, the hormonal rollercoaster of perimenopause makes things even trickier: falling oestrogen and progesterone throw the body clock off balance, making deep sleep harder just when the brain needs it most (5)
The accumulation of glucose and its metabolites in cells, for example in diabetes patients, enables this monosaccharide to interact with amino acid residues, which leads to the production of AGEs (168)
The reason for the model selection was the fact that livers are highly populated with human hepatocytes and that the major human drug metabolizing enzymes and transporters are active in the liver
It is therefore possible that the underlying neurobiological mechanisms, while leading to similar clinical presentation of fatigue and brain fog, may differ between these groups
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