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[10] [11] [12] In the TMD domain a fulcrum of polar residues regulates the biased signaling of the receptor [10] while the transmembrane helical boundaries [13] and extracellular surface are a trigger for biased agonism
These conditions and causes include emphysema, asthma, allergic disorders, drug toxicity, metabolic disorders, cancer, chemotherapy and human immunodeficiency virus-acquired immune deficiency syndrome, among others
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