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A proof-of-concept trial published in the Journal of Headache and Pain investigated liraglutide, an earlier GLP-1 receptor agonist, in patients with migraine and obesity
doi: 10.1152/ajpendo.00577.2005 49 NakamuraTTanimotoHMizunoYOkamotoMTakeuchiMTsubamotoYet al
Moreover, despite the encouraging preclinical performance of 3PO, its clinical evaluation has been delayed due to several challenges, including poor solubility, low selectivity, and the necessity for high dosages to achieve therapeutic potency [49]
However, the strength of appetite reduction can feel overwhelming at first, leading some patients to eat too little or skip meals entirely
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