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Although biting is rare, it is a significant defensive action for the Gila monster, and being bitten can be extremely painful and dangerous, requiring prompt medical attention

Seek emergency medical care immediately for severe symptoms - persistent severe abdominal pain, vomiting that won't stop, signs of allergic reaction (swelling, difficulty breathing, rash), or symptoms of low blood sugar (shaking, sweating, confusion)

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The docking score (G = 7.82 0.49 kcal/mol) reflects this diffuse, lower-affinity engagement, aligning with previous reports of carotenoids indirectly influencing efflux kinetics