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Then, the model rats were further divided into four groups: model (FC), low-dose BDF (BDF-L), high-dose BDF (BDF-H), and Maren pill (MP)

Additionally, rectal administration can result in higher bioavailability and faster onset of action compared to some other routes, as the medication bypasses the first-pass metabolism in the liver

By modulating angiogenesis and vascular integrity, these drugs may contribute to optimizing cerebral blood flow and nutrient delivery to neurons, thereby promoting overall brain health and potentially mitigating neurodegenerative processes