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If you tighten glycemic control very tightly very quickly, you can have a paradoxical effect where actually the eye disease gets worse for a period of time. In other words, rather than being a secondary effect of the drug, the worsening of DR and maybe NAION could be secondary to what the drug does in the body

For instance, while the d-amino acid substitution strategy can markedly enhance peptide resistance to proteolysis, it could also affect the conformation and efficacy of the modified peptides

6 Morin hydrate as an adjuvant to overcome cisplatin resistance and toxicity in liver cancer Cisplatin resistance in liver cancer is driven by PARP1-mediated autophagy via the HMGB1 pathway

If glucose readings are elevated, checking for ketones may be warranted, particularly if accompanied by symptoms such as nausea, vomiting, abdominal pain, rapid breathing, or confusion, which could indicate diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS) requiring urgent medical attention