Unlike prior reviews, which often present descriptive overviews, this article emphasizes comparative evaluation of design principles, biological mechanisms, and translational hurdles, including biosafety, tumor heterogeneity, and large-scale manufacturability
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The presence of an extra X chromosome (Klinefelter syndrome) or an extra Y chromosome, the presence of two X but no Y chromosome in a male, and microdeletions or translocations affecting the X or Y chromosome are examples of chromosomal problems that can disrupt sperm production and overall genital and gonad development, resulting in azoospermia (absence of sperm) and infertility