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Interestingly, defects in mitochondrial energy metabolism are also present in the brains of patients with AD, leading to neuronal apoptosis and A deposition, which increases ROS production by interfering with mitochondrial calcium homeostasis and ETC function
Was the outcome clinically meaningful
This can lead to high levels of the drug in the body and an increased risk of side effects like muscle pain and liver damage
Make sure to take small sips rather than chugging water if your goal is to prevent some of the side effects of GI upset
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