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144,145 Increased intestinal permeability has been shown to be an issue in individuals with IBS-D and has been associated with visceral hypersensitivity

| BPC-157 is a synthetic peptide derived from a naturally occurring protein in gastric juice, primarily studied for its tissue-protective and regenerative effects

27 Subsequently, they investigated a triple agonist capable of simultaneously targeting the GLP-1R, the GCGR, and the GIPR

Delivery Method (Injection vs Oral) As covered in detail in the Best Forms of BPC-157, oral BPC-157 may be cleared faster but has local effects on the GI tract , while injectables lead to systemic distribution