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Generally, taking a shot a day late is slightly safer because it ensures there is no risk of medication stacking. However, taking it a day early is also fine for most people as long as you follow the minimum gap of 48 to 72 hours

Keep in mind, this information does not contain all possible drug interactions

If a pharmacy has not conducted sterility testing and stability studies on a particular formulation, USP 797 provides default BUD limits that are quite conservative, often just 14 days or less for certain preparation categories

A second, more recent analysis (Lee and Kim, DMRR 2026) found no significant signal for tirzepatide once it had been statistically adjusted