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A combination of Lactobacillus mali APS1 and dieting improved the efficacy of obesity treatment via manipulating gut microbiome in mice
The in vitro study protocols are outlined in Fig
This effect was fully suppressed by the microglial inhibitor minocycline and the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580, underscoring the essential role of microglial activation and the p38 MAPK pathway [72]
Even as participants sense of reduced appetite eased over time, what they actually ate at controlled test meals barely budged, staying well below the placebo groups for the entire study
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