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Int J Mol Sci 19 , (2018)

In the presence of these additional molecules, the S4 transmembrane helix is shifted relative to the other pVSD helices (S1S3), causing movement of the S4S5 linker helix and triggering opening of the pore

Polymers 4 , 1478 (2012)

As evident from the above discussions, researchers have mostly correlated the cellular radiosensitivity with the GPx activity level which is majorly contributed by GPx1 (because of its higher abundance) [1, 8, 9]