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10.1152/physrev.00034.2006 57 HolstJ

NAC supports healthy levels of glutathione by providing the body with cysteine, the rate-limiting factor (a factor that prevents the process from happening more quickly) of glutathione production thus, depleted cysteine can lead to depleted glutathione

According to the US Food and Drug Administration (FDA) prescribing information: Take Rybelsus on an empty stomach in the morning with water (up to 4 ounces of water) Do not take the tablet with other liquids besides water Swallow tablets whole

This is why protease inhibitors are sometimes included in nasal peptide formulations