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Critically, to bridge the gap to real-world effects, the system would also incorporate a dynamic tier for in vivo evidence, distinguishing between effects validated in animal models versus human trials and noting known bioavailability limitations

Trust your gutliterally in some cases, too, here

"GLP-1 receptor agonists mitigate neuroinflammation, they mitigate oxidative stress, (and) they mitigate a number of things which occur systemically but also in the brain," Nigel Greig, principal investigator at the National Institute on Aging, told ABC News

Different patient populations, different trial designs, different enrollment criteria, and different measurement protocols all introduce noise that makes precise numerical comparisons between CagriSema and tirzepatide unreliable