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Yu R, Hang Y, Tsai HI, Wang D, Zhu H
(6) When to pursue functional testing despite a high value Functional markers are most useful when the clinical picture argues for deficiency even though the total looks fine
Later maladaptive hypertrophy often shows substrate inflexibility, mitochondrial dysfunction, oxidative stress, impaired calcium handling, and fibrosis
They are not interchangeable, and the more interesting question is not "which wins?" but "do they reinforce each other?" This article compares the two on mechanism, evidence, and practical use and then examines the documented and theoretical basis for combining them, including the important safety limits
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