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4.2 Exogenous stimuli-responsive hydrogels for targeted cartilage repair in osteoarthritis Exogenous stimuli-responsive hydrogels can undergo structural transitions or release therapeutic payloads in response to exogenous cues, thereby activating chondrogenic programs and promoting cartilage regeneration and reconstruction
Each contributes something unique, and together they accomplish more than any single worker could alone
Waddington, C
Each of the three pathways contributes different effects: GI Side Effects (Primarily from GLP-1) The GLP-1 component is responsible for most gastrointestinal side effects because it slows gastric emptying and affects gut motility: Metabolic Effects (From Glucagon Component) The glucagon component may cause slight increases in: Heart rate: Average increase of 5-10 bpm due to increased metabolic rate (similar to tirzepatide) Body temperature: Some users report feeling warmer, especially after meals (thermogenesis) Energy levels: Variable
