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Vasorelaxation at least 60% by 3 M ACh in rings pre-contracted with 3 M PE was considered endothelium intact

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However, CagriBB has equivalent potency to Cagri, in CRE-reporter assays in mammalian cells expressing AMY 3 Rs (Supplementary Table 4), suggesting there is negligible impact of this rotamer difference

Cueto-Urea C, Ramrez-Expsito MJ, Mayas MD, Carrera-Gonzlez MP, Godoy-Hurtado A, Martnez-Martos JM (2023) Glutathione peroxidase gpx1 to gpx8 genes expression in experimental brain tumors reveals gender-dependent patterns