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Case methodology disclosed Health Canada reviewed 15 cases of suicide, self-harm and suicidal/self-harm ideation in patients using GLP-1 RAs, including 3 Canadian and 12 international reports, with 2 drawn from published literature

By identifying the gut microbiome as an active player in the effects mediated by GLP-1 instead of a mere passive factor, this review puts forth a conceptual framework designed to clarify the variability in therapeutic responses and to inform the creation of personalized GLP-1 strategies that take the microbiome into account

The trade-off is dramatically reduced efficacy

Some medications can change how others work, making them more or less effective