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However, at therapeutic doses, the net effect of the racemic mix is predominantly that of a cardiac beta 1 stimulant, with little change in peripheral resistance (Westfall et al, 2018)
46 In rat model of OA, the nuclear localization of Nrf2 enhanced by Transient Receptor Potential Vanilloid (TRPV)-1 activation via the Ca 2+ /calmodulin-dependent protein kinase II (CaMKII)/Nrf2 signaling pathway inhibited M1 macrophage polarization in synovium, thus attenuating OA progression
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