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comparing liraglutide 1.2 mg/day + metformin 1000 mg BID combination therapy and liraglutide 1.2 mg/day alone in nondiabetic women with PCOS and obesity, again despite a significant improvement in anthropometric parameters in both groups, the combined therapy was associated with a significant reduction in fasting and 120 min glucose levels during OGTT [60]

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GLP-1s show broad mental health benefits in studies, including reductions in depression, anxiety, and neuroinflamation, as discussed below

Findings were supported by a recently updated metanalysis of 15 trials involving 898 patients were included in this analysis, GLP-1R agonists were found to have a positive impact on left ventricle diastolic function, hypertrophy, and exercise capacity [90]