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Methodological Quality and Risk of Bias Assessment We used the Cochrane Risk of Bias 2 (RoB 2) tool (crossover extension where applicable) for assessing the risk of bias to evaluate the methodological quality of RCTs

[22] Symptoms of B12 Deficiency Signs of B12 deficiencies include [23] [24] [25] [26] [27] Chronic fatigue Psychiatric problems Neurological problems Increased risks of Alzheimers disease Intergenerational neurological disorders B12 Dosage

The results showed that SOD and GR activities were significantly increased 12 h after cold treatment

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