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Curr Ther Res 1985;38:256-264

KLOW provides researchers with an opportunity to investigate how multiple peptide signaling pathways interact to regulate cellular communication, inflammatory physiology, tissue adaptation, and the biological mechanisms responsible for maintaining structural integrity under changing physiological conditions

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In the advancement of treatment strategies, although approaches like mitochondria-targeted antioxidants (e.g., MitoQ) and macrophage metabolic reprogramming (e.g., SDH inhibitors) have shown significant efficacy in animal models, their clinical translation faces severe challenges in targeted delivery and microenvironment adaptation