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Clinical trials demonstrate these medications decrease triglycerides by 15-25%, lower LDL cholesterol by 3-7%, and modestly increase HDL cholesterol

Side effects of these medications, including delayed gastric emptying, impact perioperative management, and the efficacy of oral contraception for patients on tirzepatide

Thus, although an important point to keep attention to, data so far does not indicate that cardiovascular complications are a major cause for concern at the moment (gastrointestinal problems being by far the larger problem experienced by people on GLP1R agonists )

To put that in perspective, you'd need massive amounts of oral supplements to come close to these therapeutic doses - and most wouldn't make it to your cells intact