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The CV benefits of the SGLT2 inhibitor on HF and CV death (primarily driven by HF) are observed with months and most likely are hemodynamically driven (simultaneous reduction in preload and afterload), while those of GLP-1s on MACE take 12 to 16 months to be seen and most likely are related to the drugs antiatherogenic effects
Glutathione, vitamin C, and cysteine use in autistic children with disruptive behavior: a double-blind, placebo-controlled crossover pilot study
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Because it is selective for the GLP-1 receptor, it functions in comparative work as the reference point against which dual and triple agonists are measured: an effect that semaglutide reproduces is a GLP-1-receptor effect, and an effect it does not reproduce is evidence that a second or third receptor is doing something
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