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Low protein intake, as in Madras and Soweto, impairs CYP induction: thus, the rate of theophylline clearance in Madras controls was lower than in Manchester controls, but significantly increased in local non-alcoholic patients (44), alongside regular close exposure to kerosene fumes and little ascorbic acid (36, 103)

The paper confirms this directly using an in vitro human BBB model derived from CD34+ stem cells co-cultured with brain pericytes

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The amount of non-liposomal Vitamin C absorbed in the blood decreases dramatically as the dose size increases