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2022 (NEJM Phase 1 trial)
This has led to Victoza and Saxenda lawsuits
Emamipour N, Vossoughi M, Mahboudi F, Golkar M, Fard-Esfahani P (2019) Soluble expression of IGF1 fused to DsbA in SHuffle T7 strain: optimization of expression and purification by Box-Behnken design
The most common were nausea (28.6%, 38.4% and 42.4% vs 14.8%), diarrhoea (25.2%, 34.1% and 32.0% vs 13.5%), constipation (23.8%, 25.9% and 26.1% vs 10.9%), vomiting (10.6%, 22.8% and 25.3% vs 4.8%), and upper respiratory tract infection (14.2%, 12.2% and 13.1% vs 11.6%)
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