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In this case, the affinity would weaken if Glu was replaced with a lactam bridge because the charge would be dispersed

doi: 10.3389/fendo.2024.1465881 Received 18 July 2024 Accepted 28 August 2024 Published 20 September 2024 Volume 15 - 2024 Edited by Xiaosheng Tan, Rutgers, United States Reviewed by Xiaodong Zou, The Chinese University of Hong Kong, Shenzhen, China Xue Wan, Mayo Clinic, United States Xun Sun, Indiana University, United States Updates Copyright 2024 Ji, He, Min, Yang, Wu, Xu, Chen and Mei

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Its levels decrease with age, affecting both health and appearance, and contributing to diseases like cancer, diabetes, and neurological disorders