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Statements Author contributions GM, LB and AT contributed to develop the theory, to the design and implementation of the research and to the writing of the manuscript

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For GLP-1 reconstitution in Bacteriostatic Water, the DPP-IV inhibitor requirement for biological matrix applications applies regardless of reconstitution vehicle , Bacteriostatic Water itself does not contain DPP-IV activity, but any subsequent addition to biological matrices requires DPP-IV inhibitor supplementation

Randomised, double-blind, placebo-controlled dose-escalation studies show that CJC-1295 produces sustained, dose-dependent increases in growth hormone and IGF-1, lasting several days after subcutaneous administration.[18] Ipamorelin has published human pharmacokinetic and pharmacodynamic data,[19] and has undergone a randomised phase-II study for postoperative ileus after bowel surgery.[20] But endocrine activity is not a dermatological outcome