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Here's what changed, the modern evidence on hormone therapy safety, and what it means for you
Discuss individual treatment goalsweight loss magnitude, metabolic improvement, tolerability prioritiesalongside your provider's assessment of your genetic and metabolic profile
The Phase 2 dose-finding trial (N=338), published in the New England Journal of Medicine in 2023 (DOI: 10.1056/NEJMoa2301972), randomized participants with obesity (BMI 30-50) to retatrutide at doses ranging from 0.5mg to 12mg weekly or placebo over 48 weeks
In areas that brightened slowly , the risk was elevated but not statistically significant
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