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Several practical factors may explain fatigue during GLP-1 therapy: Reduced food intake due to appetite suppression can lead to lower energy consumption Gastrointestinal side effects like nausea can be physically draining Adaptation to metabolic changes as your body adjusts to the medication For people with diabetes who take insulin or sulfonylureas (like gliclazide) alongside GLP-1 medications, low blood glucose (hypoglycaemia) may cause fatigue

Others prefer evening injections so they can sleep through the initial side effects

Post-surgical support

B12 is especially beneficial for individuals who have difficulty absorbing B12 from food or oral supplements, which can occur due to certain digestive disorders, age-related changes, or specific medical conditions