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While there is no official clinical guidance supporting this practice, individual tolerance patterns vary, and patients should discuss timing strategies with their healthcare provider if side effects are problematic
In male patients, pseudo-gynaecomastia (fat-only, not glandular) responds well distinguishing it from true gynaecomastia is essential before treatment
Clinical trial results discussed in this article - STEP 1 (14.9% average body weight loss with semaglutide), SURMOUNT-1 (20.9% average body weight loss with tirzepatide), and SELECT (20% reduced risk of major cardiovascular events with FDA-approved Wegovy in a specific patient population) - relate to studied active ingredients and specific FDA-approved formulations in controlled trial populations and should not be interpreted as guaranteed outcomes for any individual patient or compounded formulation
bioRxiv (2022)
