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Patient-centred models similarly appreciate the significance of psychosocial and quality-of-life end points, such as fatigue, cognitive function, pain, emotional well-being and treatment-related nausea or neuropathy that are commonly endorsed by patients in explaining their motivation to take supplements (236)

Conversely, the release of inflammatory cytokines promotes the progression of ferroptotic cell death, such as the inhibition of GPX4 expression in tumour necrosis factor--treated cells (Fig

However, further research is needed to fully elucidate the contribution of their antioxidant effects to clinical outcomes in acute MIRI and to explore their optimal use in this specific context