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Q1 2023 presentation, page 15

Single-cell multi-omics and spatial transcriptomics will define spatiotemporal immunological heterogeneity at the lesion level, while lung-on-a-chip platforms reproducing the cigarette smoke microenvironment (143) enable high-throughput screening of upstream interceptors (Anticalins, RORt inhibitors), downstream node-specific inhibitors (ACT1, p38 MAPK), and adjunctive modulators (NR1D1 agonists, NAD + precursors, SCFA-based microbiome therapies)

On the other hand, GSH exerts a negative feedback inhibition on GCL

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