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10.1152/ajpendo.1989.257.6.E916 Am J Physiol-Endocrinol Metab
Electron microscopy of initial IMCD principal cells from rats fed 8% protein showed expanded Golgi bodies and prominent autophagic vacuoles, and morphometric analysis demonstrated a marked increase in the surface density and boundary length of the basolateral plasma membrane
Consequently, CHAC1 acts as a critical mediator in the apoptosis pathway triggered by metabolic stress due to GCDH inhibition, highlighting its importance in the potential therapeutic targeting of melanoma (Verma et al., 2022)
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