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Aminesincluding arginine, proline, and methionine sulfoxidewere upregulated while serotonin and sarcosine were downregulated, suggesting an SSRI effect on urea cycle, one-carbon metabolism, and serotonin uptake

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There is growing evidence that the dysregulation of the NEI axis contributes to chronic inflammation, which is a factor in age-related diseases such as cancer, metabolic syndrome, cardiovascular disease, and neurodegenerative disorders
The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice
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