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However, the hyperglycemic effects of glucagon pose a challenge for its therapeutic application [77]
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Similar effects have been demonstrated in rodent MSC, where treatment with Ex at 10ng/ml 2.4 nM led to upregulation of pancreatic genes such as PDX-1 , GLUT2 and Insulin as well as an increase in DTZ-positive cells [53, 54]
Most require BMI 30, or BMI 27 with at least one obesity-related comorbidity (hypertension, dyslipidemia, prediabetes, sleep apnea, osteoarthritis)
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