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Orforglipron (36 mg) reduced HbA1c levels by an average of 1.5% in 40 weeks (10 months) in clinical trials
However, the status of the mice was closely monitored during the subsequent treatment and no significant weight loss or extreme weakness was detected
GLP-1 may also affect systemic energy metabolism by stimulating thermogenesis in brown adipose tissue and browning of white adipose tissue [43]
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