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GLP-1RAs can cross the bloodbrain barrier and activate brain GLP-1 receptors, leading to neuroprotection by improving insulin signaling, reducing tau hyperphosphorylation, and enhancing cognitive function in diabetic and aging models
Gallbladder complications Acute cholelithiasis (gallstones) was reported in at least one participant receiving 4.5 mg weekly cagrilintide in the phase 2 trial
Conclusion The mechanistic differences between retatrutide and semaglutide represent significant advances in therapeutic peptide development
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