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First of all, intracellular iron generally exists in the form of Fe 2+ , which can produce OH through the Fenton reaction, and then react with polyunsaturated fatty acids in the plasma membrane to produce ROS, resulting in iron-regulated death
CJC-1295 with DAC suits a narrower set of situations where sustained elevation is specifically desired, and it comes with the trade-offs of departing from pulsatile physiology
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