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Trials (2017) 18:255
Tirzepatide doses range from 2.5 mg to 15 mg
Priority was given to original research articles, including meta-analyses of clinical trials, and those most pertinent to the scope of this review
These data reinforce the potential clinical benefits of long-term therapy for people living with obesity and pre-diabetes. SURMOUNT-1 (NCT04184622) was a multi-center, randomized, double-blind, parallel, placebo-controlled trial comparing 5 mg, 10 mg, and 15 mg of tirzepatide to placebo as an adjunct to a reduced-calorie diet and increased physical activity in adults with pre-diabetes and obesity or overweight with at least 1 of the following comorbidities: hypertension, dyslipidemia, obstructive sleep apnea, or cardiovascular disease
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